Endotoxin induced uveitis
- An intravitreal (i.v.t.) injection of bacterial endotoxin stimulates an influx of inflammatory cells, predominantly neutrophils, into the anterior uvea section of the eye.
- This model is sensitive to pre-treatment with steroid, both by topical and intravitreal dosing.
- Uveitis, or intraocular inflammatory disease, is a damaging ocular condition which can cause cataracts, glaucoma, macular oedema, and eventually blindness.
- It is estimated that the incidence of visual loss due to uveitis is on a par with that of diabetes, and is the cause of 10-15% of all total blindness in the United States.
- Current therapies for uveitis, and many other chronic inflammatory disorders such as asthma, are steroids, immunosuppressive agents and non-steroidal anti-inflammatories (NSAIDS).
- These drugs do not completely control the disease processes and are not well tolerated due to the development of multiple adverse effects, and length of duration of treatment.
- Approximately 3-4 weeks
- Total cell counts in the aqueous humor
- Cytokine analysis of the anterior/posterior eye homogenate
- Histological assessment of cellular infiltration
# compared to control
* compared to LPS