Acute smoke-induced lung inflammation (steroid resistant)

Model:

  • Airway exposure to cigarette smoke produces a localised inflammation, characterised by an influx of neutrophils, which is steroid resistant.

Background:

  • Neutrophilic inflammation, which is unresponsive to steroid treatment, is a key contributor in the pathogenesis of diseases such as Asthma, COPD and Acute Lung Injury, making this a useful model for screening compounds targeting these conditions.

Animal:

  • Mice

Inducer:

  • Cigarette smoke

Study Duration:

  • Approximately 4-5 weeks

Parameter Measures:

  • BALF cellular infiltration
  • Cytokines in the Blood/BALF
  • Histology
  • Organ or fluid collection for external analysis e.g. PK analysis