Acute smoke-induced lung inflammation (steroid resistant)
- Airway exposure to cigarette smoke produces a localised inflammation, characterised by an influx of neutrophils, which is steroid resistant.
- Neutrophilic inflammation, which is unresponsive to steroid treatment, is a key contributor in the pathogenesis of diseases such as Asthma, COPD and Acute Lung Injury, making this a useful model for screening compounds targeting these conditions.
- BALF cellular infiltration
- Cytokines in the Blood/BALF
- Organ or fluid collection for external analysis e.g. PK analysis