Science Lab

Pneumolabs Publications

Knowles I., Lalgi K., Elmi M., Robb O. & Patel N. (2016). Influenza induced exacerbation of asthma is associated with steroid insensitive AHR and pulmonary inflammation in HDM-sensitised mice. Eur Respir J, 

Gil M.A., Shah S., Chen D., Cabal A., Katz J., Cicmil M., Salmon M., Lee H., Houshyar H., Bass A., Yu H., Alves S., Gardiner P., Knowles I. & McLeod R.(2016). Profiling The Effects Of PI3K-Inhibitors On Ozone-Induced Airway Inflammation, Cytokine Secretion And Oxidative Stress. Am J Respir Crit Care Med, 193: A6744.

Onions S., Ito K., Charron C., Brown R., Colucci M., Frickel F., Hardy G., Joly K., King-Underwood J., Kizawa Y., Knowles I., Murray J., Novak A., Rani A., Rapeport G., Smith A., Strong P., Taddei D. & Williams J. (2016). Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma. J Med Chem, 59(5): 1727-1746.

Coates M., Brookes D., Allen H., Fordyce E., Colley T., Hunt F., Onion S., Yim K, Knowles I., Murray P.J., Ito K., Strong P. & Rapeport G. (2016). Preclinical characterization of a novel anti-respiratory syncytial virus agent, PC786. Poster presented at Macrae Foundation’s XVIII International Symposium on Respiratory Viral Infections.

Tannu S.A., Renzetti L.M., Tare N., Ventre J.D., Lavelle D., Lin T.A., Morschauser A., Paciorek J., Bolin D.R., Michel H., Singer L., Hargaden M., Knowles I., Gardiner P., Cazzola M., Calzetta L., Matera M.G. & Hicks A. (2010). Duel bronchodilatory and pulmonary anti-inflammatory activity of RO5024118, a novel agonist at vasoactive intestinal peptide VPAC2 receptors. Br J Pharmacol, 161: 1329-1342.

Cooper, N., Walker, I. & Knowles, I.D. (2006). NVA237 and Tiotropium Bromide demonstrate similar efficacy in an anesthetized rabbit model of Methacholine-Induced bronchoconstriction. NVA237 demonstrates a reduced systemic pharmacological effect on cardiovascular parameters. Proc Am Thor Soc, 3: A117.

Cooper N., Walker I. & Knowles I. (2006). NVA237 has similar efficacy as tiotropium bromide against methacholine (MCh)-induced bronchoconstriction and less systemic effect on cardiovascular variables in an anaesthetized rabbit model. Eur Resp Congress, 2544.

Adcock J., Douglas G., Garabette M., Gascoigne M., Beatch G., Walker M. & Page C. (2003). RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol, 138(3): 407-416.