Science Lab

Pneumolabs Publications

Knowles, I., Lalgi, K., Elmi, M., Robb,O. & Patel, N. (2016). Influenza induced exacerbation of asthma is associated with steroid insensitive AHR and pulmonary inflammation in HDM-sensitised mice. Submitted for Eur. Resp. Soc. Congress

Malgorzata A. Gil, Sanjiv Shah, Dapeng Chen, Antonio Cabal, Jason Katz, Milenko Cicmil, Michael Salmon, Hyun-Hee Lee, Hani Houshyar, Alan Bass, Hongshi Yu, Stephen Alves, Philip Gardiner, Ian Knowles, Robbie McLeod (2016). Profiling The Effects Of PI3K-Inhibitors On Ozone-Induced Airway Inflammation, Cytokine Secretion And Oxidative Stress. AM. J. Resp. Crit. Care Med., 193, A6744

Coates, M., Brookes,D., Allen, H., Fordyce, E., Colley, T., Hunt, F., Onion, S., Yim, K, Knowles, I., Murray,P.J., Ito, K., Strong, P. & Rapeport, G. (2016). Preclinical characterization of a novel anti-respiratory syncytial virus agent, PC786. Macrae Foundation’s XVIII International Symposium on Respiratory Viral Infection’s

Pulmocide present at the Macrae Foundation’s XVIII International Symposium

Onions, S., Ito, K., Charron, C., Brown, R., Colucci, M., Frickel, F., Hardy, G., Joly, K., King-Underwood, J., Kizawa, Y., Knowles, I., Murray, J., Novak, A., Rani, A., Rapeport, G., Smith, A., Strong, P., Taddei, D. & Williams, J. (2016). Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma. J. Med. Chem., 59, 1727-1746.

Tannu, S.A., Renzetti, L.M., Tare, N., Ventre, J.D., Lavelle, D., Lin, T.A., Morschauser, A., Paciorek, J., Bolin, D.R., Michel, H., Singer, L., Hargaden, M., Knowles, I.D., Gardiner, P., Cazzola, M., Calzetta, L., Matera, M.G. & Hicks, A. (2010). Duel bronchodilatory and pulmonary anti-inflammatory activity of RO5024118, a novel agonist at vasoactive intestinal peptide VPAC2 receptors. Br. J. Pharmacol., 161, 1329-1342.

Cooper, N., Walker, I. & Knowles, I.D. (2006). NVA237 and Tiotropium Bromide demonstrate similar efficacy in an anesthetized rabbit model of Methacholine-Induced bronchoconstriction. NVA237 demonstrates a reduced systemic pharmacological effect on cardiovascular parameters. Proc. Am. Thor.Soc. 3:A117.

Cooper, N., Walker, I. & Knowles, I.D. (2006). NVA237 has similar efficacy as tiotropium bromide against methacholine (MCh)-induced bronchoconstriction and less systemic effect on cardiovascular variables in an anaesthetized rabbit model. Eur. Resp. Congress. 2544.

Adcock, J., Douglas, G., Garabette, M., Gascoigne, M, Beatch, G., Walker, M. & Page, C. (2003). RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br. J. Pharmacol., 138, 407-416.