- Systemic allergen sensitisation, followed by intranasal allergen challenge, produces a localised inflammation consisting of predominantly eosinophils.
- Steroid sensitive.
- Allergic sensitisation to inhaled allergens, such as dust or grass pollen, causes nasal irritation and inflammation.
- Sufferers may develop an itchy, runny nose which can become congested, and itchy, watery eyes.
- Although symptoms are often mild, those with more severe rhinitis can find it quite debilitating.
- Common treatments include antihistamines and steroids, are not preventative but aim to reduce symptom severity.
- P.O., I.P., I.T. S.C., I.N. and I.V.
- Approximately 4 weeks
- NALF cellular infiltration
- Cytokines in the NALF
Time course data
**p<0.01 v sham