Acute Lung Injury
- Airway exposure to bacterial endotoxin produces a robust localised neutrophilic inflammation.
- Neutrophilic inflammation is a key contributor in the pathogenesis of diseases such as COPD and Acute Lung Injury, making this a useful model for screening compounds targeting either condition.
- Mice and Rats
- Lipopolysaccharide (LPS)
- P.O., I.P., I.T. S.C., I.N. and I.V.
- Approximately 1-2 weeks
- BALF cellular infiltration
- Cytokines in the Blood/BALF
- Organ or fluid collection for external analysis e.g. PK analysis
- Western Blot
Mouse BALF Cell Data
Mouse BALF Cytokine Data
*compared to sham
*compared to corresponding untreated group