- Exposure to a citric acid/capsaicin aerosol induces a cough which can be inhibited by codeine.
- Chronic cough is a common symptom of respiratory diseases such as asthma, COPD and allergic rhinitis. Anti-tussive medications are amongst the most widely used drugs in the world and most have poor efficacy and/or side-effect profiles.
- Guinea Pig, Rabbit
- Citric Acid/Capsaicin
- P.O., I.P., I.T. S.C., I.N. and I.V.
- Approximately 2 weeks
- Latency of cough onset
- Frequency of coughs min-1
- Total number of coughs
- Plasma for PK analysis
Effect of codeine on citric acid-induced cough responses in the guinea pig
Effect of codeine on capsaicin-induced cough responses in the guinea pig