Asthma (Steroid sensitive)
- Animals are sensitized systemically with either house dust mite (HDM) in Freund’s adjuvant or ovalbumin (OVA) in aluminium hydroxide, and following this receive a single airway challenge of the respective allergen.
- This steroid sensitive model demonstrates many of the hallmark features of human allergic asthma, such as a predominantly eosinophilic inflammation of the airways, production of Th2 cytokines, and changes in lung function.
- Mouse, Rat and Guinea Pig
- Ovalbumin or House Dust Mite
- P.O., I.P., I.T. S.C., I.N. and I.V.
- Approximately 3-5 weeks
- BALF cellular infiltration
- Cytokines in the Blood/BALF/Lung
- Lung function
- Western Blot
Mouse Models – Ovalbumin (OVA)
Mouse Models – House Dust Mite (HDM)
N.B. Groups are labelled according to: Sensitization agent + Challenge agent + Treatment
*=compared to HDM sensitization + HDM challenge group