Asthma exacerbation (influenza)
- Influenza infection following acute allergen sensitisation to house dust mite produces a localised inflammation, characterised by an influx of eosinophils, neutrophils, and mononuclear cells, which is steroid insensitive.
- This model demonstrates exacerbation of both Th1 and Th2 cytokines, and inflammatory cell infiltrates of the BAL fluid, as well as airway hyperresponsiveness.
- Influenza A (IVA) is a common respiratory infection often resulting in acute exacerbations amongst asthmatics. Drug treatment e.g. steroids for exacerbations are generally less effective resulting in increased hospitalization and mortality amongst asthmatics, making this a highly relevant and useful model for screening compounds targeting this condition.
- House dust mite and mouse adapted influenza A virus
- P.O., I.P., I.T. S.C., I.N. and I.V.
- Approximately 4-6 weeks
- BALF cellular infiltration
- Cytokines in the Blood/BALF/Lung
- Viral Titre
- Lung function
- Western Blot
Viral titre dose-response
N.B. UV refers to ultra-violet inactivated IVA
* compared to respective saline group
Time course data
N.B. Viral Titre 1 x 103 PFU
Steroid data (Dexamethasone)
# compared to naïve
* compared to HDM/HDM + UV IVA
N.B. Viral Titre 1 x 104 PFU