Alternaria Alternata

Model:

  • Intranasal (i.n.)  administration of Alternaria induces an influx of neutrophils, eosinophils and cytokines primarily associated with TH2-type inflammation 24 hours following challenge in BAL fluid.

Background:

  • Alternaria alternata is a fungal spore that can cause exacerbation of symptoms in asthma patients. This model serves as an alternative to other steroid sensitive models, mimicking several key aspects of human allergic asthma over a shorter duration.

Animal:

  •  Mouse

Inducer:

  • Alternaria alternata

 Study Duration:

  • 24 hours

 Parameter Measures:

  • Total cell counts
  • Cytokine profile analysis
  • Histological assessment of cellular infiltration

 Cell Data

Intranasal administration of Alternaria induces a significant increase in the number of total inflammatory cells, neutrophils and eosinophils in BAL fluid after 24 hours.